Enzyme-Specific Activation versus Leaving Group Ability
نویسندگان
چکیده
منابع مشابه
Enzyme-Specific Activation versus Leaving Group Ability
Enzyme-specific activation and the substrate mimetics strategy are effective ways to circumvent the limited substrate recognition often encountered in protease-catalyzed peptide synthesis. A key structural element in both approaches is the guanidinophenyl (OGp) ester, which enables important interactions for affinity and recognition by the enzyme--at least, this is usually the explanation given...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2012
ISSN: 1439-4227
DOI: 10.1002/cbic.201200227